Summarized by Masters of Longevity from PR Newswire.
Reports that an international phase III trial found brain MRI surveillance alone reduced cognitive decline compared with MRI plus prophylactic cranial irradiation in small-cell lung cancer patients.
Key Takeaways
- MRI surveillance alone reduced the risk of cognitive failure or death by 40% versus MRI plus PCI (HR 0.60; 90% CI 0.46–0.78).
- Preliminary overall survival showed no clear difference between strategies (HR 0.90; 90% CI 0.67–1.20) after 128 deaths.
- Grade 3–5 treatment-related adverse events occurred in 0.8% with MRI alone versus 7.9% with MRI plus PCI (p=0.004).
