Mitochondrial surface engineering using PEG lipids and attached peptides: a short article previewing methods to stabilize and enhance uptake of isolated mitochondria.
Key Takeaways
- PEGylation created a protective hydration layer on isolated mitochondrial surfaces
- Cell penetrating peptides were attached to PEGylated mitochondria via maleimide linkages
- CPP-PEG-modified mitochondria showed improved cellular internalization and increased respiratory activity