Summarized by Masters of Longevity from Nature - Biotechnology.
Reports an orthotopic gene‑modified pig-to-human liver transplant in a brain‑dead donor, tracking graft function, coagulation, and immune responses over 11 days.
Key Takeaways
- The xenograft produced continuous albumin and bile with normal composition for 11 days, but at relatively low levels.
- Progressive thrombocytopenia and reduced clotting factor activity developed alongside microthrombosis and suboptimal hepatic perfusion.
- Histology showed minimal T and B cell infiltration but strong innate activation with IgM-mediated complement deposition.
