Longevity News

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

Source: Nature - Biotechnology • Published: 14 Aug 2026, 00:00

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

Reports a multicenter phase II trial testing an oral nonpeptide GLP-1 receptor agonist for obesity, its dosing options, and short-term efficacy and tolerability.

Key Takeaways
  • We conducted a multicenter, randomized, double-blind, placebo-controlled
  • Primary endpoint was the percentage change in body weight from baseline to week 16
  • Two-hundred and fifty participants were randomized (61 to placebo, 189 to VCT220)
Read Original Source