Longevity News

Novel RNA aptamer HPE3 suppresses angiogenesis via inhibiting endocan–VEGF-A formation in Matrigel-implanted mice

Source: Nature - Biotechnology • Published: 21 Aug 2026, 00:00

Novel RNA aptamer HPE3 suppresses angiogenesis via inhibiting endocan–VEGF-A formation in Matrigel-implanted mice

Report on a new high-affinity RNA aptamer that blocks endocan–VEGF-A interactions and reduces pathological angiogenesis in preclinical models.

Key Takeaways
  • Histological staining and hemoglobin quantification confirmed its anti-angiogenic effects
  • It is citable and carries a permanent DOI
  • This version is subject to further edits and will be replaced automatically by the final Version of Record
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