Electrically neutral self‑assembling peptides as a design approach for safer mRNA delivery are examined, highlighting the article’s focus and reader value.
Key Takeaways
- Electrically neutral self-assembling peptides coassemble with mRNA into discrete nanotube-shaped complexes
- ENSP-based mRNA vehicles showed almost no cytotoxicity in mammalian cells compared with cationic carriers
- ENSP complexes exhibited negligible detergent-like membrane activity toward red blood cells in vitro and in vivo