Examines whether soluble factors in low birth weight newborns' cord plasma inhibit NETosis and whether that activity can reverse lupus-like immune pathology.
Key Takeaways
- Disruption of this equilibrium can lead to pathological immune activation and autoimmunity
- Neutrophil dysfunction has emerged as an important contributor to SLE pathogenesis
- Neonatal immune system is exposed to extensive antigenic stimuli during the early postnatal period ( 11 )