Summarized by Masters of Longevity from Frontiers - Health.
Review synthesizes recent advances in hepatic macrophage biology across chronic liver diseases, emphasizing metabolic rewiring, spatial heterogeneity, and intercellular and interorgan crosstalk.
Key Takeaways
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- Beyond the outdated binary M1/M2 classification, tissue-resident macrophages (ResMø) and recruited monocyte-derived macrophages (MDMs) differentiate into disease-specific subsets (LAMs, SAMs, SenAMs) with spatially restricted, context-dependent functions.
- Macrophage-derived autophagy, LC3-associated phagocytosis (LAP), and exosomal cargo transfer represent pivotal functional executors mediating intercellular signal transmission.
