Summarized by Masters of Longevity from Fight Aging!.
A mouse-research feature outlining a midlife genetic manipulation study that assesses effects on aging, health measures, and liver cell gene programs.
Key Takeaways
- A tamoxifen-inducible growth hormone receptor knockout at 12 months produced classical GH resistance with lower circulating IGF-1 and higher GH levels in mice.
- Midlife Ghr ablation modestly extended lifespan under study conditions and improved male insulin sensitivity and neuromuscular and bone measures.
- Single-nucleus RNA-seq of livers showed reduced B-cell abundance and sex-dimorphic transcriptional remodeling, including feminized gene programs in male hepatocytes.
