Summarized by Masters of Longevity from Lifespan.io.
Covers research testing midlife interruption of growth hormone signaling in mice and its sex-specific effects on lifespan and physiology.
Key Takeaways
- Midlife knockout of the growth hormone receptor extended mouse lifespan, especially in females.
- GHR knockout produced substantial IGF-1 reductions, with the effect stronger in males.
- Male knockouts improved insulin sensitivity and preserved vertebral trabecular bone integrity.
