Summarized by Masters of Longevity from Frontiers - Health.
Reports that MGST3 marks an M2-like macrophage state with preserved mitochondrial function in atherosclerotic plaques and links to lower inflammation.
Key Takeaways
- MGST3 was prioritized by integrative WGCNA, machine learning, and MR as the top mitochondrial-associated candidate gene for atherosclerosis.
- Two-sample Mendelian randomization found higher genetically predicted MGST3 expression associated with lower CAD/CHD risk (training OR 0.989; test OR 0.977).
- MGST3-high M2-like macrophages showed OXPHOS-oriented, antioxidant transcriptional profiles and knockdown reduced M2 and mitochondrial transcripts while increasing pro-inflammatory transcripts.
