Examines focused ultrasound-responsive bi-layer nanobubbles as a noninvasive strategy to locally deliver small molecules across the blood-brain barrier.
Key Takeaways
- SF6-core bi-layer nanobubbles showed lower inertial cavitation and ultraharmonic emissions at 0.4 MPa
- Curcumin-loaded nanobubbles increased neuronal cell delivery eightfold under FUS compared to free drug
- Optimized FUS parameters produced localized BBB penetration in mice without significant neurotoxicity