Summarized by Masters of Longevity from Frontiers - Health.
Liver-eye axis research linking fatty liver and diabetic retinal disease using genetic, proteomic, and single-cell approaches; a multi-modal mechanistic investigation.
Key Takeaways
- Mendelian randomization tested causal relationships between NAFLD genetic liability and diabetic retinopathy stratified by non-proliferative and proliferative stages.
- Proteome-wide MR across three blood pQTL datasets identified circulating proteins associated with genetic risk for diabetic retinopathy.
- Follow-up analyses included colocalization, mediation testing, single-cell sequencing, and clinical sample validation to prioritize liver-derived mediators.
