Summarized by Masters of Longevity from Fight Aging!.
This piece previews a research article about how a specific immune checkpoint protein helps aging cells evade clearance, and how targeting it might reinvigorate immune removal of those cells.
Key Takeaways
- Senescent human cells and aged tissues show increased PD-L2 expression compared with younger counterparts.
- Old PD-L2 knockout mice accumulate fewer senescent cells and exhibit improved insulin sensitivity and grip strength.
- Anti-PD-L2 treatment in aged wild-type mice restored insulin sensitivity and reduced senescent cell markers.
