Survey of how intestinal stem cells actively sense microbial, immune, metabolic, mechanical, and neural cues and adapt epithelial fate and repair.
Key Takeaways
- Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and tissue repair
- ISC niche is increasingly viewed as a dynamic signaling network rather than a static structural compartment
- Persistent or dysregulated environmental sensing can disrupt adaptive epithelial responses