Summarized by Masters of Longevity from Longevity Technology.
A Yale-led meta-analysis harmonized 51 intervention studies and standardized epigenetic clock outputs to assess whether interventions change DNA methylation aging measures.
Key Takeaways
- Pooling 51 studies and 3,128 blood samples, researchers calculated 16 epigenetic clocks and 94 methylation biomarkers using one pipeline.
- Thirteen interventions still showed significant decreases after multiple-testing correction, while 26 interventions showed no significant change and five increased age.
- Senolytic interventions lacked reproducible, directionally consistent effects across biomarkers and studies, failing the authors' reproducibility criteria.
