Summarized by Masters of Longevity from Frontiers - Health.
Genetic, proteomic, transcriptomic, and retinal single-cell analyses converge on ICAM-5 as a candidate mediator and circulating biomarker for immune-mediated non-infectious uveitis.
Key Takeaways
- Mendelian randomization linked higher genetically predicted ICAM5 expression and protein levels to increased uveitis risk with significant odds ratios.
- Plasma ICAM-5 concentrations were elevated in three uveitis subgroups versus healthy controls after age and sex adjustment.
- Retinal single-cell RNA-sequencing localized Icam5 expression mainly to neuronal populations while blood transcriptomics showed increased ICAM5 in cases.
