A systematic review synthesizes evidence linking pediatric gastroesophageal reflux and proton pump inhibitor exposure to gastrointestinal microbiota changes across aerodigestive compartments.
Key Takeaways
- Study selection was performed according to PRISMA guidelines, 31 of which were included in the final analysis
- PPI exposure has been frequently associated with increased numbers of oropharyngeal bacteria in the gut
- Several studies have reported an association between PPI and small intestinal bacterial overgrowth