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Enhancing early diabetic retinopathy detection: a fine-tuned NASNet framework with robust validation and external generalization

Source: Frontiers - Health • Published: 19 Aug 2026, 00:00

Enhancing early diabetic retinopathy detection: a fine-tuned NASNet framework with robust validation and external generalization

Early diabetic retinopathy screening using a fine-tuned deep‑learning NASNet framework; a technical article detailing model development, validation, and generalization.

Key Takeaways
  • Fine-tuned NASNetLarge model achieved 97.52% ± 0.42 accuracy on the APTOS 2019 dataset
  • External validation on EyePACS produced 93.42% accuracy and an AUC of 0.941
  • NASNetLarge outperformed EfficientNet-B4, DenseNet121, and ViT-B16 under identical evaluation conditions
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