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Development of PEG-biotin mixed micelles for myricetin delivery and their anti-colorectal cancer efficacy

Source: Nature - Biotechnology • Published: 07 Sept 2026, 00:00

Summarized by Masters of Longevity from Nature - Biotechnology.

Reports a biotin-decorated PEG-PVP mixed micelle that improves myricetin delivery and shows enhanced anti-colorectal cancer effects in cells, rats, and patient-derived organoids.

Development of PEG-biotin mixed micelles for myricetin delivery and their anti-colorectal cancer efficacy
Key Takeaways
  • Biotin-decorated MYR@Bi-PEG-PVP formed ~154 nm nanoparticles with 87.99% encapsulation efficiency and 12.18% drug loading.
  • MYR@Bi-PEG-PVP increased cellular uptake and produced stronger growth inhibition and anti-invasion in HCT116 cells compared with free MYR and non-targeted micelles.
  • In rats, MYR@Bi-PEG-PVP prolonged half-life to 3.87 hours and raised AUC0–24 to 27.23 μg·h/mL and Cmax to 9.25 μg/mL versus free MYR.
Read the full article at Nature - Biotechnology ↗

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