Longevity News

Development and internal validation of an interpretable mammography-based model for malignancy risk stratification in BI-RADS 4 breast lesions

Source: Frontiers - Health • Published: 12 Aug 2026, 00:00

Development and internal validation of an interpretable mammography-based model for malignancy risk stratification in BI-RADS 4 breast lesions

A study presents an interpretable mammography-based model to better stratify malignancy risk within BI-RADS 4 breast lesions and compares model variants.

Key Takeaways
  • Retrospective model used 441 BI-RADS 4 lesions and found 165 malignancies
  • Full mammography model achieved an optimism-corrected AUC of 0.841 versus 0.770 for BI-RADS alone
  • Final predictors included BI-RADS 4B/4C, architectural distortion, shape and texture mammographic features
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