Describes a biomimetic artificial cell platform that reproduces mechanical and biochemical features of immunological synapses to study T cell interactions and activation.
Key Takeaways
- Mechanical force-driven signaling has emerged as a key regulator of cell–cell interactions (CCIs)
- We demonstrate that kpiCells can engage in physiological CCIs and reproduce critical subcellular features
- KpiCells enable integrated interrogation of afferent mechanosensing pathways and efferent force-exertion pathways