Summarized by Masters of Longevity from Lifespan.io.
Assessing how various epigenetic aging clocks respond across intervention types to identify useful surrogate endpoints for human trials.
Key Takeaways
- Analysis aggregated data from 51 longitudinal interventional studies comparing DNAm biomarkers.
- Pharmacological interventions produced stronger DNAm biomarker responses and larger effect sizes.
- Tumor necrosis factor reducing therapies and Mediterranean diets showed reproducible biomarker modulation.
