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Comparative efficacy and safety of seven Chinese patent medicines combined with SSRIs for depressive disorder: a systematic review and network meta-analysis

Source: Frontiers - Health • Published: 14 Aug 2026, 00:00

Comparative efficacy and safety of seven Chinese patent medicines combined with SSRIs for depressive disorder: a systematic review and network meta-analysis

This article reviews comparative evidence on different Chinese patent medicines added to SSRIs for depressive disorder, helping readers judge study types and comparisons.

Key Takeaways
  • Combining Chinese patent medicines with SSRIs significantly improved depressive symptoms compared with SSRIs alone
  • Jieyu Wan (JYW)+SSRIs ranked highest for HAMD improvement
  • Safety profiles showed no statistically significant differences in adverse drug reactions
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