Summarized by Masters of Longevity from Fight Aging!.
A study reports that reducing calorie intake in mice lowered accumulation of nuclear DNA mutations across multiple tissues, with variable effects by tissue and genomic region.
Key Takeaways
- Calorie restriction reduced substitution, insertion, and deletion mutation burdens in multiple mouse tissues.
- Liver cells showed a larger mutation reduction from calorie restriction than kidney or brain cells.
- Mutation reductions were greatest in genomically inactive regions in liver and kidney cells.
