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Bispecific chimeric autoantibody receptor T cells eliminate acetylcholine receptor-specific B cells in myasthenia gravis models

Source: Nature - Biotechnology • Published: 20 Aug 2026, 00:00

Bispecific chimeric autoantibody receptor T cells eliminate acetylcholine receptor-specific B cells in myasthenia gravis models

Covers development and preclinical testing of bispecific chimeric autoantibody receptor T cells targeting two acetylcholine receptor subunits in myasthenia gravis models.

Key Takeaways
  • IgLON5-Fc served as a negative control antigen
  • Dots show the results of each technical replicate
  • C Expression of AChRa1 CAAR and AChRb1 CAAR in primary human T cells was validated by flow cytometry
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