Covers a ligand-free polymer–lipid nanoparticle that activates T cells and delivers mRNA systemically to generate CAR T cells in vivo.
Key Takeaways
- ERTLNPs engaged the PI3K/AKT/mTOR signalling axis to reprogram T cell metabolism
- Which efficiently eliminated pathological fibroblasts in models of cancer and fibrosis
- 4: Mechanistic profiling of ERTLNPs-mediated T cell activation