Reports on a sonication-based amplification assay that measures trace misfolded amyloid-β in plasma to detect Alzheimer’s disease and related impairment.
Key Takeaways
- Real-time sonication-based PMCA assay measured plasma amyloid-β seeding activity in 549 participants
- Assay distinguished AD from cognitively unimpaired controls with AUC = 0.93 using an optimal cutoff
- Plasma amyloid-β seeding activity correlated with cognition, with MMSE rs = -0.68 and CDR rs = 0.71