Metformin as a potential anti-aging drug: a critical review of research literature that guides readers through the types of studies and evidence available.
Key Takeaways
- Animal studies of metformin show mixed effects on lifespan and heterogeneous methodologies
- Human trial evidence for reduced mortality or increased life expectancy is limited and methodologically questionable
- MeMeMe trial found metformin reduced progression to type 2 diabetes but did not lower cancer