Covers new cell-based evidence that SIRT1 limits age-linked genomic instability by repressing retrotransposon activity and downstream damage.
Key Takeaways
- SIRT1 overexpression reduced LINE-1 promoter activity and lowered ORF2 production in human cells
- SIRT1 knockdown increased DNA damage markers and raised senescence rates after radiation exposure
- SIRT1 enrichment at LINE-1 loci in quiescent cells suppressed retrotransposition and inflammatory SASP factors