Reports on mouse research linking the APOE4 Alzheimer’s risk gene to early neuron shrinkage and hippocampal hyperactivity, and intervention reversing those changes.
Key Takeaways
- APOE4 in mice increased the protein Nell2 and caused neuronal shrinkage and hyperactive hippocampal circuits
- Early hippocampal hyperexcitability in APOE4 mice predicted worse memory performance later in life
- Reducing Nell2 in adult APOE4 mice reversed neuronal and network abnormalities and improved outcomes