Summarized by Masters of Longevity from Fight Aging!.
A narrative review evaluates aging clocks, classifies them into three generations, and examines their biological basis, methods, and translational challenges.
Key Takeaways
- Aging clocks are categorized as first-generation (chronological age predictors), second-generation (morbidity and mortality risk estimators), and third-generation (longitudinal pace-of-aging measures).
- Mechanistic signals informing clocks include methylome remodeling, immunosenescence, and chronic low-grade inflammation as emphasized by the review.
- Major limitations include limited biological specificity, confounding and reverse causation risks, poor generalizability, and scarce longitudinal mechanistic validation.
