Feature
MOTS-c: Where the Evidence Ends
Studies offer clues about ageing and metabolism. What do they actually tell us about human health—and where does expert opinion take over?
Nature Aging
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
A harmonized single-cell compendium of more than 375,000 endothelial cells across 12 tissues showed age-associated transcriptional changes.
Key takeaways
- The atlas was built from 375,000 cells across 12 human tissues.
- A p21-linked programme was found in senescent endothelial models.
- Venous cells showed age-linked declines in angiogenic gene expression.
