Masters of Longevity - The Pulse

Youtube — Eric Topol31 Aug 2026
Single-cell epigenetics cracked it #substack #shorts (Youtube — Eric Topol)

Single-cell epigenetics cracked it #substack #shorts

Single-cell epigenetics: a short piece introducing a study-style explainer that shows how epigenetic profiling uncovers cell identities overlooked by RNA-only approaches and why combined single-cell multiomic work matters.

Key takeaways
  • Single-cell epigenetic profiling revealed microglia identities missed by single-cell RNA sequencing.
  • Findings indicate many aged brain samples contained embryonically derived microglia not previously recognized.
  • Speakers call for continued single-cell genetics and epigenetics work to expand understanding of brain aging.
MoL Event Pick
Longevity Wellness Expo 2026 (Toronto, Canada)

Longevity Wellness Expo 2026

2. OCT 2026 - 4. OCT 2026 - Toronto, CanadaExpo

Toronto expo and conference focused on longevity, wellness, biohacking, health optimization and healthy aging products and services.

Science Daily - Health & Medicine30 Aug 2026
A cancer therapy put severe rheumatoid arthritis into remission (Science Daily - Health & Medicine)

A cancer therapy put severe rheumatoid arthritis into remission

CD19 CAR T-cell therapy is the focus of a clinical report that readers can open to learn about a novel immunotherapy approach for severe rheumatoid arthritis and its potential to reset autoimmune responses.

Key takeaways
  • Six people with refractory seropositive rheumatoid arthritis received CD19 CAR T-cell therapy in a phase 1 trial.
  • Three participants achieved medication-free clinical remission after treatment.
  • Authors propose the therapy clears pathogenic B cells and reboots immune regulation, but larger trials are needed.
Nature - Biotechnology30 Aug 2026
AIEffect of RNA minimum free energy and spacer on silencing of four Sclerotinia sclerotiorum virulence genes (Nature - Biotechnology)

Effect of RNA minimum free energy and spacer on silencing of four Sclerotinia sclerotiorum virulence genes

Examines how siRNA/miRNA structural energy and inclusion of spacers affect RNA silencing of four fungal virulence genes in plant disease control.

Key takeaways
  • It is citable and carries a permanent DOI.
  • This version is subject to further edits and will be replaced automatically by the final Version of Record.
  • For this, double-stranded RNA (dsRNA), individually and as a combination of genes, was synthesized in vitro.
Frontiers - Health29 Aug 2026
AIIntegrated CDK4/6 Inhibitor Resistance and Primary-Metastatic Discordance in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer: A Translational F

Integrated CDK4/6 Inhibitor Resistance and Primary-Metastatic Discordance in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer: A Translational Framework Focused on Invasive Ductal Carcinoma With Gastric Metastasis

Presents a translational framework linking genomic resistance signatures and primary‑metastatic phenotype discordance in HR+/HER2‑ metastatic breast cancer focusing on invasive ductal carcinoma with gastric spread.

Key takeaways
  • Five-module CDK4/6 inhibitor resistance score was developed from mutation and copy‑number events.
  • High-resistance/high-discordance tumors were enriched for PI3K-axis, chromatin-remodeling, and RB-axis events.
  • Metastases showed higher resistance scores and greater proliferation activity than primary tumors.