A comparative study of how von Willebrand factor shapes vegetation formation in two Streptococcus mutans endocarditis mouse models and the underlying inflammatory signals.
Key Takeaways
- VWF deficiency markedly reduced valve colonization and vegetation size in damage-induced S
- Supplementing VWF restored vegetation formation phenotypes in VWF-deficient mice
- VWF promoted IL-17A and ICAM-1 upregulation