Examine how an immunometabolic regulator reshapes activated CD4+ T-cell metabolism to support proliferation via enhanced glutamine-dependent pathways.
Key Takeaways
- VitD-treated CD4+ T-cell cultures expanded despite decreased glucose uptake and lactate production
- Proteomics showed upregulation of glutaminase, glutamate dehydrogenase, and CD38 expression
- Pharmacological blockade of VDR, glutamine uptake, or glutaminase reduced T-cell expansion