A short analysis of research using a vertebrate model to illustrate antagonistic pleiotropy and its consequences for life-history trade-offs.
Key Takeaways
- Disruption of vgll3 isoforms accelerated male growth and earlier maturation dose-dependently
- Mutant males showed elevated germline and intestinal stem-cell proliferation
- Older mutants developed melanoma-like tumors and had shortened lifespans validated by transplant