Skeletal aging research: an inviting preview of a preclinical paper on a novel mRNA delivery strategy aiming to support bone health.
Key Takeaways
- Transcriptomic analysis found MMP9 consistently upregulated in elderly human serum and bone samples
- Apoptosis-mimicking phosphatidylserine LNPs were used to deliver mRNA selectively to macrophages
- In aged mice, macrophage-produced anti-MMP9 antibodies reduced circulating MMP9 and improved bone structure