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Urinary nephrin as an early biomarker of podocyte dysfunction in essential hypertension: a stage-stratified study from Bukhara, Uzbekistan

Source: Frontiers - Health • Published: 03 Jul 2026, 00:00

Urinary nephrin as an early biomarker of podocyte dysfunction in essential hypertension: a stage-stratified study from Bukhara, Uzbekistan

Examination of an early podocyte injury biomarker across hypertension stages and its change after nephroprotective therapy in a Central Asian cohort.

Key Takeaways
  • Urinary nephrin increased across stages from approximately 92 to 165 ng/mL
  • Nephrinuria correlated with systolic blood pressure, aldosterone, eGFR, and RFR
  • Nephrinuria decreased 23–32% after six months of nephroprotective treatment
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