Summarizes a study identifying microRNA regulation of Hippo pathway effector YAP1 and its impact on tumor cell growth in models.
Key Takeaways
- MiR-195 directly binds the YAP1 3' UTR and abolishes reporter activity when the seed site is intact
- MiR-195 overexpression reduces endogenous YAP1 protein and lowers CTGF expression in cultured cells
- Stable miR-195 overexpression suppressed xenograft tumor growth and low miR-195 correlates with poorer patient survival