Reports how total-body irradiation followed by hematopoietic stem cell transplant alters immune recovery and bones over time in a murine arthritis model.
Key Takeaways
- Irradiation plus HSCT caused systemic vulnerability including reduced body weight and thymic atrophy
- Trabecular bone loss occurred after irradiation and HSCT and worsened in the arthritic limb
- Immune recovery was time-dependent with early granulocyte expansion and delayed lymphocyte increases