Spinal-disc cell transplantation explored in a preclinical canine study that compares therapeutic responses across controlled degeneration severities.
Key Takeaways
- Off-the-shelf Tie2-enriched nucleus pulposus cells improved disc height index and histology scores
- Regenerative effects occurred in both mild and severe degeneration with comparable outcomes
- Human cell persistence was detected by immunohistochemistry after implantation in the canine discs