A mini-review summarizes evidence that methylation of a distal TERT promoter region called THOR commonly associates with increased telomerase expression across many cancers and explores its biomarker potential and technical challenges.
Key Takeaways
- Methylation of the TERT Hypermethylated Oncological Region (THOR)
- Many cancers reportedly exhibit telomerase activity in the absence of these mutations
- Epigenetic regulation of the TERT locus has gained increasing attention