Research explores genetic and microbiome contributors to a little-understood, widespread lung disease and previews an experimental therapy tested in animal models.
Key Takeaways
- Mice lacking the Tlr5 gene developed more severe fibrosis and lower survival after lung injury
- Tlr5-deficient mice showed reduced lung microbial diversity and diminished antimicrobial activity
- Drug that activates TLR5 signaling and reduced fibrosis in mice