Assess advances connecting lactate-driven protein modification with inflammatory and malignant skin conditions, and its translational therapeutic angle.
Key Takeaways
- Protein lactylation is a lactate-derived post-translational modification regulating gene transcription
- Lactylation has been implicated in psoriasis, melanoma, atopic dermatitis, scarring, and skin ageing
- Lactylation-related inhibitors show therapeutic potential across cancer