Longevity News

The “Mechano-Metabolic-Immune” crosstalk within the skeletal muscle microenvironment: evolution of homeostatic remodeling and quality control mechanisms

Source: Frontiers - Health • Published: 14 Jul 2026, 00:00

The “Mechano-Metabolic-Immune” crosstalk within the skeletal muscle microenvironment: evolution of homeostatic remodeling and quality control mechanisms

A review examining how mechanical, metabolic, and immune interactions shape skeletal muscle quality and guide mechanism-driven precision exercise strategies.

Key Takeaways
  • Given that the biological benefits of mechanical intervention are constrained by physiological thresholds
  • Substantial evidence has demonstrated that skeletal muscle exhibits remarkable biological plasticity
  • This pathological cross-talk between the joint and muscle not only accelerates skeletal muscle degeneration
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