Reports how tertiary lymphoid structures shape tumour-specific CD8+ T cell states in renal cell carcinoma and their spatial interactions within tumours.
Key Takeaways
- TLS-containing RCC tumours are more heavily infiltrated by exhausted CD8+ T cells compared with TLS-negative tumours
- From 554 expanded T cell clonotypes, 82 TCRs showed reactivity against tumour cells or RCC antigens
- Subset of tumour-specific clonotypes (12%) enriched in TLSs exhibited a stem-like progenitor exhaustion program