Report on a connectome-guided PET study showing how localized tau in a movement disorder links to a shared distant cortical circuit tied to cognition.
Key Takeaways
- Researchers mapped tau PET in 37 progressive supranuclear palsy patients and combined it with healthy connectome data
- Common PSP-tau network was identified linking subcortical tau sites to prefrontal
- Strength of connectivity between tau sites and the PSP-tau network correlated with frontal cognitive impairment severity