Report on synthetic voltage-dependent potassium channel inhibitors that trigger stomatal closure and boost plant drought tolerance by altering guard cell ion dynamics.
Key Takeaways
- Chemical screen identified NS5806 as a KAT1 inhibitor reducing channel activity by about 55%
- Rationally designed analog, UA49, increased KAT1 inhibition to 79% and showed stronger KAT2 inhibition
- NS5806 and UA49 raised cytosolic Ca2+ in guard cells and enhanced plant drought resistance when applied