Reports mapping how three-dimensional subnuclear compartments reorganize during human cortical neurogenesis and regulate bivalent chromatin states and transcriptional activation.
Key Takeaways
- Poised state of bivalent genes embedded in the lamina
- Our analyses established subnuclear genome compartmentalization as a key regulator of bivalency
- Functional experiments demonstrated that the lamina represses transcription independently of local H3K27me3